Parents often find themselves bewildered and distressed when their children suddenly exhibit neurological or psychiatric symptoms following a seemingly minor infection. These symptoms could be indicative of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) or Pediatric Autoimmune Neuropsychiatric Disorders (PANDAS).

PANS and PANDAS are conditions triggered by the body’s immune response to an infection. In the process of fighting off the infection, the immune system can mistakenly cause inflammation in the brain, leading to a rapid onset of new and concerning symptoms. At The James Clinic, we specialize in diagnosing and treating these complex conditions to help children regain their health and well-being.

Understanding PANS/PANDA

These conditions, estimated to affect 1 in 200 children, can be challenging to diagnose and require the expertise of experienced healthcare professionals. Here’s a closer look at the data and our approach at The James Clinic:

Age of Onset

PANS and PANDAS can manifest at various ages, though certain age groups are more commonly affected:

  • 1 to 3 years: 11% – Symptoms can appear very early, often complicating early childhood development.
  • 4 to 9 years: 69% – The majority of cases begin during early childhood, a critical period for neurological and behavioral development.
  • 10 to 13 years: 19% – Onset during later childhood can impact school performance and social interactions.
  • 14+ years: 1% – Rare but possible, late onset can overlap with other adolescent health issues.

Primary Symptoms

The symptoms of PANS and PANDAS can vary widely, often mimicking other conditions, which makes accurate diagnosis crucial:

  • Obsessive compulsive disorder (OCD): 37% – Many children develop sudden, severe OCD, significantly disrupting daily life.
  • Tics: 14% – Involuntary movements or vocalizations are common, often causing social and functional difficulties.
  • Both: 49% – Nearly half of the children experience a combination of OCD and tics, complicating the clinical picture.

Infections Reported

Infections are a common trigger for PANS and PANDAS, with certain pathogens being more frequently associated:

  • Strep: 81% – Group A streptococcal infections are the most common trigger, linking PANDAS specifically to strep infections.
  • Other (Mycoplasma, Lyme, etc.): 19% – Other infections, including Mycoplasma pneumoniae and Lyme disease, can also trigger PANS, necessitating a broad diagnostic approach.


We take a thorough, multi-faceted approach to treating PANS and PANDAS:

  • Diagnosis: We start with a comprehensive assessment to accurately diagnose the condition, including detailed medical history and specialized tests.
  • Lifestyle: Initial focus on optimizing diet, sleep, and hydration to support overall health and reduce symptom severity.
  • Supplements and Medications: Personalized plans that may include vitamins, minerals, and prescription medications to address specific deficiencies and symptoms.
  • IV Therapies: Intravenous treatments to deliver essential nutrients and medications directly into the bloodstream for quick and effective results.
  • Hyperbaric Oxygen Therapy: Enhances oxygen delivery to tissues, reducing inflammation and promoting healing.
  • Ozone Therapy: Utilizes ozone gas to improve oxygen utilization and support the immune system.
  • Advanced Therapies: For more severe cases, we offer cutting-edge treatments like TruDose PRP, which can reduce inflammation and support recovery.

Symptoms We Treat

Obsessive compulsive disorder (OCD) / Tics / Movement disorders / Mood issues (such as anxiety or depression) / Aggressive behavior / Regression in behavior / Cognitive issues / New onset of bedwetting / Insomnia

Frequently Asked Questions

Here you’ll find the answers to help you make informed decisions about your health journey.

Diagnosing PANS and PANDAS involves a comprehensive assessment that includes a detailed medical history, a physical examination, and specialized diagnostic tests. We look for sudden onset of neuropsychiatric symptoms following an infection, such as OCD, tics, or severe mood changes. Blood tests may be conducted to identify underlying infections or immune responses. Our thorough approach ensures an accurate diagnosis, which is crucial for developing an effective treatment plan.

We offer a holistic and personalized treatment approach for PANS and PANDAS. Our treatment options include lifestyle modifications focusing on diet, sleep, and hydration, as well as supplements and prescription medications tailored to the patient’s needs. We also provide advanced therapies such as IV nutrient therapy, hyperbaric oxygen therapy (HBOT), ozone therapy, and TruDose PRP to reduce inflammation and promote recovery. Each treatment plan is customized to address the unique needs of the patient, ensuring comprehensive care and support.

Listen to Dr. James talk about children care and working with us.