Bioidentical Hormone Replacement Therapy

Hormone Health · Women & Men

For thirty years, you've been told hormones are dangerous.
The data never said that.

Bioidentical hormone therapy for women and men — guided by individualized risk assessment from the same physicians who run our Terrain Oncology Program.

Chesterfield, MO · Ankeny, IA · Chariton, IA · Virtual visits available

The 2002 Story

One headline changed medicine.
The fine print never made the news.

In 2002, the Women’s Health Initiative study was halted early, and headlines announced that hormone therapy causes breast cancer. Doctors pulled millions of women off hormones almost overnight. Here’s what the study actually showed.

+8 in 10,000

The actual increase in breast cancer cases per year in the combined-hormone arm — under 0.1% in absolute terms, reported to the public as a frightening “26% increase.”

The average age of WHI participants — more than a decade past menopause, on synthetic hormones. Nothing like a 51-year-old starting bioidentical therapy today.

Fewer

Breast cancers in the estrogen-only arm than in women taking placebo. The arm of the study nobody talks about.

~80%

The collapse in hormone therapy use in the years after the headlines — millions of women left to suffer through menopause unsupported.

The risk was misrepresented for a generation. The suffering it caused was not hypothetical.

Sources: Women’s Health Initiative (JAMA 2002); WHI estrogen-alone arm (JAMA 2004; long-term follow-up); Sarrel et al., American Journal of Public Health, 2013.

The Real Cost

Avoiding hormones isn't the safe choice. It's just a different risk.

Tens of thousands of premature deaths

Researchers estimate that as many as 91,000 women aged 50–59 died prematurely in the decade after 2002 — women who had hysterectomies and avoided estrogen therapy that the evidence supported. Heart disease, not breast cancer, is the #1 killer of women, and estrogen started near menopause is protective of the cardiovascular system.

Decades of unnecessary suffering

Hot flashes, sleepless years, bone loss, brain fog, depression, painful intimacy — dismissed as “just menopause” and left untreated. Meanwhile men with collapsing testosterone were told fatigue, weight gain, and low mood were “just aging.” Neither had to be endured. They still don’t.

Who We Treat

Hormones run the whole body.
For everybody.

For Women

Perimenopause & menopause, taken seriously.

Bioidentical estrogen, progesterone, and testosterone — dosed to your labs, your symptoms, and your risk profile, then monitored over time.

You are not "too young," "too old," or "just stressed."

For Men

Low testosterone is a medical problem — not a punchline

Testosterone optimization built on real diagnostics — total and free T, the full metabolic and cardiac picture — with physician monitoring, not a franchise protocol.

"Just getting older" is not a diagnosis.

Individualized Risk Assessment

We run a cancer program. Risk assessment is our specialty.

Most clinics prescribing hormones have never managed cancer risk. We assess it every day. The same terrain-based evaluation behind our Terrain Oncology Program informs every hormone decision we make — your genetics, your family history, your labs, your biology.

Personal and family cancer history, evaluated — not just asked about
Genetic and terrain markers that shape your individual risk
Baseline and ongoing monitoring, with dosing adjusted to the data
An honest conversation about your numbers — both risks: treating, and not treating

Your risk isn’t a statistic from 2002.
It’s yours.

Every hormone decision at James Clinic starts with your individual risk profile — not a 24-year-old headline.

HOW IT WORKS

Three steps. Zero runaround.

1. Book a free discovery call

Tell us your symptoms, your history, and your concerns. We'll tell you honestly whether we can help.

2. Get the full hormone picture

Comprehensive hormone, metabolic, and risk testing — far beyond the single TSH or total-T your last physical checked

3. Optimize, monitor, adjust

A bioidentical protocol built for your biology, monitored over time and tuned as your body responds.

"No hormones. Ever."

It's more complicated than that.

If you’re a breast cancer or prostate cancer survivor — or carry a strong family history — chances are someone delivered that verdict in a single sentence, with no discussion. But the research on hormone use after cancer is far more nuanced than a blanket “never,” and for many survivors, a carefully individualized approach is possible.

We can have that conversation.

A real one — your pathology, your treatment history, your current terrain, and what the published evidence actually shows for someone in your position.

The decision stays yours.

Full informed consent, honest numbers on both sides, careful monitoring, and coordination with your whole care team. No pressure in either direction — just a decision made with you, not for you.

Hormone therapy after cancer is an individualized medical decision made between you and your physician after a complete evaluation. It is not appropriate for everyone — which is exactly why it deserves a real assessment instead of a reflex.

      EXCELLENT  
   Based on 63 reviews 
    
 
 
 
   
 
 
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   Dave Greene 
 
 
 
 Trustindex verifies that the original source of the review is Google. The entire staff is very friendly and sincerely interested your health. I have had blood tests done that my insurance primary has never heard of and that revealed issues that he was unaware of.  James clinic diagnosed the cause and cured tge problem. They are the best!
  
 
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   steven marchant 
 
 
 
 Trustindex verifies that the original source of the review is Google. The James Clinic is like stepping into a different world,they care about their patients!
I've been with them several years, it's a five hour drive for me. They seem more like family
That's hard to find! I would suggest the James Clinic 100 percent.
  
 
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   Deanna Martin 
 
 
 
 Trustindex verifies that the original source of the review is Google. I love the James Clinic and everyone there! I have learned so much about how to improve my health and not just how to treat my symptoms. They are so real there. They talk to you. They engage on a personal level and really care about my health and wellness. I feel very in control of my healthcare rather than being controlled by the provider or insurance company. I highly recommend this clinic and its providers!!
  
 
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   Maria C 
 
 
 
 Trustindex verifies that the original source of the review is Google. Exceptional from the staff at the front door, throughout the clinic, the advance practice HCPs and Dr. James herself!  Do yourself a favor and make the investment in your OPTIMAL state of health.  Come educated. Come curious.  They love having discussions.  The testing and health optimization tools they offer are exceptional.
  
 
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   Brad Smyth 
 
 
 
 Trustindex verifies that the original source of the review is Google. I cannot say enough positive things about Dr James and her entire staff.  We work primarily with Sara Taylor, NP, and she has been nothing short of amazing.  Our whole family, including my two teenage boys, have been with them for over a year now and we are thankful every day that we found them.  One of my teenage sons has ASD, on top of numerous health issues and the attention Sara and the team has given to help him has been life changing!
  
 
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   Brett & Connie Roberts 
 
 
 
 Trustindex verifies that the original source of the review is Google. Sara Taylor is awesome! She has taken care of all my outpatient needs for more than 18 months! 10/10 all the time
  
 
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   Jennifer Lyman 
 
 
 
 Trustindex verifies that the original source of the review is Google. In addition to being incredibly knowledgable, I really appreciate the care Kate takes with her patients. It's very valuable to me that they are functional medicine physicians/NPs at this practice vs those who wear the doctor title without having medical training.
  
 
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   Joanne Curran 
 
 
 
 Trustindex verifies that the original source of the review is Google. NPs Justina Timms and Sarah Taylor are always incredibly well prepared, knowledgeable and take all the time needed to explain labs and test results to me in ways that I can understand. Their professionalism and expertise continue to astound me. They also check in after procedures or explanations with well documented follow up.  In addition, every nurse at the clinic is warm, friendly, personable, knowledgeable and professional to the Nth degree! Theresa, Michelle, Whitney, Lauren, Brenda, Mary and Chelsea all work hard and are extremely timely when completing procedures such as HBOT and MDI treatments. I have nothing but the highest regard for the James Clinic and all who work there including their lead Dr. Mollie James. My gratitude runs deep for their services.

Feel like yourself again.

One free, unhurried conversation — your symptoms, your history, and an honest answer about whether hormones are right for you.

Chesterfield, MO · Ankeny, IA · Chariton, IA · Telehealth

Hormone Health · Women & Men

For thirty years, you've been told hormones are dangerous.
The data never said that.

Bioidentical hormone therapy for women and men — guided by individualized risk assessment from the same physicians who run our Terrain Oncology Program.

Chesterfield, MO · Ankeny, IA · Chariton, IA · Virtual visits available

The 2002 Story

One headline changed medicine.
The fine print never made the news.

The risk was misrepresented for a generation. The suffering it caused was not hypothetical.

The Real Cost

Avoiding hormones isn't the safe choice. It's just a different risk.

Tens of thousands of premature deaths

Decades of unnecessary suffering

Who We Treat

Hormones run the whole body.
For everybody.

You are not "too young," "too old," or "just stressed."

"Just getting older" is not a diagnosis.

Individualized Risk Assessment

We run a cancer program. Risk assessment is our specialty.

HOW IT WORKS

Three steps. Zero runaround.

1. Book a free discovery call

2. Get the full hormone picture

3. Optimize, monitor, adjust

"No hormones. Ever."

It's more complicated than that.

We can have that conversation.

The decision stays yours.

Feel like yourself again.

Request an appointment

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Clinic Locations

Hormone Health · Women & Men

For thirty years, you've been told hormones are dangerous.The data never said that.

Bioidentical hormone therapy for women and men — guided by individualized risk assessment from the same physicians who run our Terrain Oncology Program.

Chesterfield, MO · Ankeny, IA · Chariton, IA · Virtual visits available

The 2002 Story

One headline changed medicine. The fine print never made the news.

The risk was misrepresented for a generation. The suffering it caused was not hypothetical.

The Real Cost

Avoiding hormones isn't the safe choice. It's just a different risk.

Tens of thousands of premature deaths

Decades of unnecessary suffering

Who We Treat

Hormones run the whole body. For everybody.

Individualized Risk Assessment

We run a cancer program. Risk assessment is our specialty.

HOW IT WORKS

Three steps. Zero runaround.

"No hormones. Ever."

It's more complicated than that.

We can have that conversation.

The decision stays yours.

Feel like yourself again.

The James Clinic medical team is deploying to North Carolina to provide critical aid in the aftermath of Hurricane Helene.

For thirty years, you've been told hormones are dangerous.
The data never said that.

One headline changed medicine.
The fine print never made the news.

Hormones run the whole body.
For everybody.