IV Ozone Therapy (MAH)

Ozone Therapy (MAH), a medical innovation with roots tracing back to Nikola Tesla, has gained significant traction across the United States in recent years. This therapy utilizes Ozone gas (O3), an energized form of oxygen created by passing an electric current through O2.

While commonly known for its use in sterilization, Ozone’s role in therapeutic applications is profoundly different. When administered through the blood, Ozone quickly dissipates and performs two critical functions: enhancing the body’s antioxidant defense to combat free radicals and boosting cellular energy by recycling NADH into NAD+.

At The James Clinic, we harness the power of IV Ozone Therapy to provide a wide range of health benefits, from improving mental clarity and energy levels to boosting immunity and reducing inflammation.


Major Autohemotherapy (MAH) is similar to an IV vitamin treatment, with a key difference. Initially, your blood is withdrawn into an IV saline bag and then mixed with medical ozone gas. This enriched mixture is then infused back into your body. MAH can be utilized as a stand-alone therapy or combined with other IV treatments for enhanced benefits.


Ozone therapy offers a wide array of benefits that extend beyond traditional treatments. By leveraging the power of O3, ozone therapy can significantly enhance your health in various ways. Here are some of the key benefits you can expect:
  • Boosts the immune system. Ozone therapy can activate and enhance the immune system, making it more effective at combating infections and diseases. This activation helps the body respond more vigorously to pathogens, leading to better overall health and resistance to illness.

  • Reduces inflammation. Ozone has strong anti-inflammatory properties that help alleviate inflammation throughout the body. By reducing inflammation, ozone therapy can help manage conditions like arthritis, asthma, and other chronic inflammatory diseases, improving patient comfort and mobility.

  • Improves circulation. Ozone therapy enhances blood flow and oxygen delivery to tissues, promoting faster wound healing and tissue repair. Improved circulation also supports cardiovascular health and can aid in the recovery from injuries and surgeries.

  • Provides pain relief. Ozone therapy has been shown to effectively manage chronic pain conditions, including joint pain, back pain, and headaches. By reducing inflammation and promoting healing, it offers a natural alternative to pain management without the side effects associated with many medications.

  • Fights infections. Ozone’s antimicrobial properties make it effective against bacteria, viruses, and fungi. This makes ozone therapy a valuable tool in treating infections that are resistant to conventional antibiotics, enhancing the body’s ability to fight off harmful microorganisms.

  • Enhances overall well-being. Patients undergoing ozone therapy often report improvements in energy levels, mental clarity, and overall well-being. By increasing oxygenation and supporting the body’s natural healing processes, ozone therapy contributes to enhanced vitality and quality of life.


You might experience a slight burning sensation when ozone is administered, but this is normal and usually subsides within minutes. Some people feel the effects of IV ozone therapy immediately, while for others, it might take up to a week. There’s no downtime after the treatment, so you can return to work and other daily activities right away.

Each session costs $390. We typically recommend a ‘loading dose’ of 2-3 sessions per week during the first week of therapy, followed by at least 3 additional sessions to start experiencing the benefits.

Allergic Reactions: Ozone is a known irritant and can cause respiratory problems in some individuals.

Infection Risk: Infections can occur if proper sterilization techniques are not followed during treatment.

Discomfort During Treatment: Some patients may experience mild pain or discomfort at the injection site, along with potential inflammation or tenderness after the treatment.

Oxidative Stress: While ozone has antioxidant properties, repeated exposure to the gas could lead to oxidative stress and damage to healthy cells.

Lack of FDA Regulation: Ozone IV therapy is not regulated by the FDA, leading to a lack of standardized treatment protocols. Practitioners may use varying concentrations of ozone and administer the treatment differently.


Conditions IV Ozone Therapy Treats

Viral diseases / Arthritis / Fibromyalgia / Circulatory disorders / Diabetic ulcers / Chronic infections / Autoimmune diseases / Cardiovascular diseases / Chronic fatigue syndrome / Chronic pain conditions / Cancer / Allergies / Chronic respiratory conditions

Frequently Asked Questions

Here you’ll find the answers to help you make informed decisions about your health journey.

Ozone Therapy is a highly specialized medical procedure requiring advanced equipment for administration. Our practitioners are well-versed in its application and closely monitor patients throughout the process. We tailor the use of ozone therapy to individual medical symptoms and diagnoses, ensuring it is prescribed only when it is most appropriate for the patient’s specific needs.

IV Ozone therapy, commonly known as 10-pass or Major Autohemotherapy (MAH), involves removing blood, mixing it with ozone, and then reinfusing it back into the body. This method infuses ozone into the blood but does not filter it.

In contrast, EBOO (Extracorporeal Blood Oxygenation and Ozonation) not only infuses blood with ozone but also filters it. EBOO handles a much larger volume of blood, equivalent to 40 passes of MAH in a single session. The filtration process removes plaque, biofilm, and endotoxins while continuously infusing ozone, ensuring every red blood cell is enriched with ozone.

When administered by a certified healthcare practitioner, ozone therapy is extremely safe with minimal side effects. A study titled “Accident and Typical Complications in Ozone Therapy” reported a complication rate of 0.0007% out of 5.5 million treatment sessions involving 384,775 patients, which translates to roughly 1 in every 150,000 patients treated. Most major complications arose from direct IV injection of ozone, a method not commonly used.
However, inhaling ozone gas can cause airway hyper-reactivity, inflammation, and significantly worsen conditions like COPD. Ozone therapy is not recommended for individuals with glucose-6-phosphate dehydrogenase deficiency, uncontrolled hyperthyroidism, during the first three months of pregnancy, and in certain other conditions.

During your consultation, one of our clinicians will discuss whether ozone therapy is safe and appropriate for you. We use universal safety precautions and a well-ventilated exam room to ensure patient safety.


A patient receiving MAH IV Ozone therapy.